Signs Your Kidneys Are Not Working Properly: Symptoms, Causes, Tests and Treatment
Introduction
The kidneys perform several essential functions that help maintain overall health. They filter waste products from the blood, remove excess fluid, maintain electrolyte and acid-base balance, help regulate blood pressure, and support healthy red blood cell and bone metabolism.
When kidney function begins to decline, the changes may be subtle. In fact, early kidney disease may cause few or no noticeable symptoms. As kidney dysfunction progresses, however, certain signs can develop.
Knowing the signs your kidneys are not working properly can encourage timely medical evaluation and help identify kidney disease before complications become severe.
At Prabhakar Bhurke Clinic, Dr. Sandip Prabhakar Bhurke, a super specialist nephrologist, provides comprehensive evaluation and personalized management for kidney disorders, including chronic kidney disease, acute kidney injury, kidney stones, hypertension-related kidney disease, dialysis needs and kidney failure.
What Happens When Your Kidneys Are Not Working Properly?
When kidney function decreases, the kidneys may become less effective at:
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Filtering waste products from the blood
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Removing excess salt and fluid
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Maintaining electrolyte balance
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Regulating blood pressure
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Maintaining acid-base balance
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Supporting red blood cell production
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Maintaining healthy bone and mineral metabolism
Kidney dysfunction can develop suddenly, as in acute kidney injury (AKI), or gradually over months or years, as in chronic kidney disease (CKD).
The symptoms depend on the underlying cause and how significantly kidney function has changed.
Signs Your Kidneys Are Not Working Properly
1. Changes in Urination
Changes in urination can be an important warning sign.
You may notice:
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Urinating more frequently
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Increased urination at night
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Reduced urine output
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Foamy or unusually bubbly urine
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Blood in the urine
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Dark or unusually colored urine
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Difficulty passing urine
These changes do not always mean kidney disease, but persistent or unexplained urinary changes should be evaluated.
2. Swelling in the Feet, Ankles or Face
Healthy kidneys help maintain the body's fluid balance.
When kidney function is reduced, excess salt and fluid may accumulate, resulting in edema.
Swelling may appear in:
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Feet
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Ankles
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Legs
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Hands
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Around the eyes
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Face
Sudden or significant swelling should receive medical attention, particularly when accompanied by reduced urine output or breathlessness.
3. Persistent Fatigue and Weakness
Ongoing tiredness can occur with kidney disease.
Possible reasons include:
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Waste product accumulation
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Anemia associated with CKD
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Sleep disturbances
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Changes in metabolism
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Other complications of reduced kidney function
Fatigue is common and nonspecific, so it should be assessed alongside other symptoms and medical findings.
4. Foamy Urine
Persistent foamy urine can sometimes indicate protein in the urine.
Protein leakage may occur when the kidney's filtering units are damaged.
Proteinuria can be associated with conditions such as:
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Diabetes
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High blood pressure
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Glomerular kidney diseases
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Other forms of CKD
A urine albumin or protein test can help determine whether significant protein leakage is present.
5. Blood in the Urine
Blood in the urine, known medically as hematuria, should not be ignored.
Possible causes include:
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Kidney stones
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Urinary tract infections
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Kidney disease
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Prostate or urinary tract conditions
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Certain medications
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Other urinary disorders
The cause needs to be identified through appropriate evaluation rather than assuming that blood in the urine automatically indicates kidney failure.
6. Persistent Itching or Dry Skin
Persistent itching may occur in more advanced kidney disease.
It can be associated with:
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Mineral and bone metabolism abnormalities
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Dry skin
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Waste product accumulation
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Changes involving nerves and inflammation
Not all itching is related to kidney disease. However, persistent unexplained itching combined with abnormal kidney tests should be evaluated.
7. Nausea, Vomiting or Loss of Appetite
As kidney dysfunction becomes more advanced, waste products can accumulate in the bloodstream.
This may contribute to:
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Nausea
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Vomiting
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Poor appetite
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Unpleasant or metallic taste
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Weight loss
Persistent gastrointestinal symptoms require medical evaluation because they can have many causes besides kidney disease.
8. Muscle Cramps
Kidney disease can sometimes contribute to muscle cramps because of disturbances in:
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Electrolytes
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Calcium and phosphorus metabolism
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Fluid balance
Frequent or severe muscle cramps should be discussed with a healthcare professional, especially in people with known kidney disease.
9. Shortness of Breath
Breathlessness can occur in people with significant kidney dysfunction for several reasons.
Possible contributors include:
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Excess fluid accumulation
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Anemia
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Heart-related complications
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Metabolic disturbances
New or severe shortness of breath should be evaluated promptly because it can indicate a serious medical problem.
10. Difficulty Concentrating
Advanced kidney dysfunction may affect mental clarity.
Some people may experience:
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Difficulty concentrating
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Reduced alertness
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Memory problems
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Sleepiness
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Confusion in severe cases
Sudden confusion or significant changes in consciousness require urgent medical attention.
11. High Blood Pressure
Kidney disease and high blood pressure are closely connected.
Damaged kidneys may contribute to elevated blood pressure, while uncontrolled hypertension can further damage kidney tissue.
Persistent high blood pressure therefore warrants appropriate kidney assessment, particularly when other risk factors are present.
12. Puffiness Around the Eyes
Swelling around the eyes, particularly in the morning, can sometimes occur when kidney disease causes fluid retention or significant protein loss in the urine.
However, facial or eye swelling can have many other causes, so proper evaluation is necessary.
Can Kidney Problems Cause Back or Flank Pain?
Not always.
Many chronic kidney diseases develop without pain, particularly during their early stages.
Kidney-related pain is more commonly associated with conditions such as:
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Kidney stones
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Kidney infections
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Urinary obstruction
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Hydronephrosis
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Polycystic kidney disease
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Certain structural kidney disorders
Kidney pain is usually felt in the flank or below the ribs, rather than in the center of the lower back.
Common Causes of Reduced Kidney Function
Several conditions can affect kidney function.
Diabetes
Long-standing or poorly controlled diabetes can damage the kidney's filtering system and contribute to CKD.
High Blood Pressure
Persistent hypertension can damage blood vessels within the kidneys.
Acute Kidney Injury
AKI can occur because of:
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Severe dehydration
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Infection or sepsis
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Low blood pressure
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Certain medications
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Urinary obstruction
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Major illness or surgery
Some cases of AKI can improve when the underlying cause is treated promptly.
Kidney Stones and Urinary Obstruction
A stone or another blockage can interfere with urine drainage and, in certain situations, impair kidney function.
Glomerular Diseases
Diseases affecting the kidney's filtering units can cause proteinuria, hematuria and declining kidney function.
Polycystic Kidney Disease
This inherited disorder causes multiple kidney cysts and may gradually affect kidney function.
Autoimmune Kidney Diseases
Conditions such as lupus nephritis and certain forms of vasculitis can damage the kidneys.
Who Is at Higher Risk of Kidney Disease?
You may have a higher risk if you have:
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Diabetes
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High blood pressure
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Heart disease
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Obesity
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Family history of kidney disease
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Previous acute kidney injury
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Recurrent kidney stones
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Recurrent urinary infections
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Autoimmune disease
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Long-term use of certain medicines that can affect kidney function
People with these risk factors may benefit from periodic kidney health checks even when they feel well.
How Can You Check Whether Your Kidneys Are Working Properly?
Symptoms alone cannot accurately determine kidney function.
A nephrologist may recommend several investigations.
Serum Creatinine and eGFR
A blood creatinine test is commonly used to estimate kidney filtration.
The estimated glomerular filtration rate (eGFR) helps assess the level of kidney function.
A persistently reduced eGFR can indicate CKD, but the result needs to be interpreted in the context of the patient's age, clinical condition and other findings.
Urine Albumin-to-Creatinine Ratio
The urine albumin-to-creatinine ratio (ACR) helps detect albumin leakage into the urine.
Albuminuria can be an important marker of kidney damage.
Urinalysis
Urine testing can identify:
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Blood
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Protein
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White blood cells
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Infection-related findings
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Other abnormalities
Blood Pressure Measurement
Blood pressure assessment is important because hypertension can both contribute to and result from kidney disease.
Electrolyte Testing
Blood tests may assess:
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Sodium
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Potassium
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Bicarbonate
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Calcium
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Phosphorus
These measurements can help identify complications of kidney dysfunction.
Imaging
Depending on the suspected cause, a doctor may recommend:
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Kidney ultrasound
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CT scan
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MRI in selected situations
Imaging can help identify stones, cysts, obstruction or structural abnormalities.
When Should You See a Nephrologist?
Consider consulting a nephrologist if you have:
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Persistent swelling
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Foamy urine
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Blood in the urine
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Reduced urine output
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Repeated abnormal creatinine results
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Reduced eGFR
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Persistent high blood pressure
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Protein in the urine
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Recurrent kidney stones
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Diabetes with abnormal kidney tests
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A family history of significant kidney disease
Early specialist assessment can help identify the cause and determine appropriate monitoring or treatment.
Treatment When Kidney Function Is Reduced
Treatment depends on the underlying cause and severity.
Control Blood Pressure
Maintaining appropriate blood pressure is an important part of protecting kidney function.
Your doctor may prescribe medications based on your kidney condition, blood pressure and urine protein levels.
Manage Diabetes
Good diabetes management can reduce the risk of further kidney damage in people with diabetic kidney disease.
Treat Underlying Kidney Conditions
Treatment may be directed toward:
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Kidney infections
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Kidney stones
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Glomerular diseases
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Autoimmune kidney disease
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Urinary obstruction
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Other underlying conditions
Manage Kidney Disease Complications
Depending on the stage of disease, treatment may address:
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Anemia
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Electrolyte abnormalities
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Acid-base disturbances
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Mineral and bone disorders
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Fluid retention
Dialysis
When kidney function becomes severely impaired and medical management is no longer sufficient, dialysis may be required.
Dialysis decisions are based on the overall clinical condition and complications rather than one laboratory value alone.
Kidney Transplantation
For eligible patients with advanced kidney failure, kidney transplantation may provide long-term kidney replacement and can improve quality of life and survival compared with remaining on dialysis for many suitable candidates.
Lifestyle Habits That Support Kidney Health
Healthy habits can help reduce kidney disease risk and support overall health.
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Maintain healthy blood pressure.
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Manage blood sugar if you have diabetes.
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Reduce excessive salt intake.
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Maintain a healthy body weight.
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Exercise regularly as appropriate.
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Avoid smoking.
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Take medicines only as advised.
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Avoid unnecessary use of painkillers, particularly NSAIDs.
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Drink fluids according to your doctor's recommendations.
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Attend regular kidney check-ups when you are at increased risk.
People with established kidney disease may require individualized dietary and fluid recommendations.
When Are Kidney Symptoms an Emergency?
Seek urgent medical care if you experience:
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Very little or no urine
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Severe or rapidly worsening swelling
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Severe shortness of breath
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Chest pain
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Severe confusion
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Loss of consciousness
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Seizures
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Persistent vomiting with weakness or dehydration
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Severe flank pain with fever or chills
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Difficulty passing urine with severe pain or fever
A urinary obstruction accompanied by infection can become a serious emergency and may require urgent drainage and treatment.
Why Choose Prabhakar Bhurke Clinic?
At Prabhakar Bhurke Clinic, patients receive comprehensive kidney care from Dr. Sandip Prabhakar Bhurke, a super specialist nephrologist.
The clinic provides:
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Detailed kidney function evaluation
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Assessment of abnormal creatinine and eGFR
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Urine protein and kidney health assessment
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Chronic kidney disease management
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Acute kidney injury evaluation
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Diabetes and hypertension-related kidney care
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Kidney stone and urinary obstruction assessment
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Dialysis planning and management
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Kidney transplant evaluation and guidance
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Long-term kidney health monitoring
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Personalized, evidence-based treatment
The goal is to identify kidney problems early, address their underlying causes and help protect remaining kidney function.
Frequently Asked Questions
What are the first signs your kidneys are not working properly?
Early kidney disease may cause no symptoms. When signs do occur, they can include swelling, changes in urination, foamy urine, blood in the urine, fatigue, high blood pressure and abnormal kidney blood or urine tests.
Can you have kidney disease without symptoms?
Yes. Many people with early CKD do not have obvious symptoms. Routine blood pressure, blood and urine testing can help identify kidney disease in people at risk.
Does foamy urine always mean kidney disease?
No. Temporary foaming can occur for several reasons. Persistent foamy urine may indicate protein in the urine and should be evaluated.
Is high creatinine always a sign of kidney failure?
No. Creatinine can rise for several reasons, including acute kidney injury, dehydration, certain medicines and other factors. A doctor needs to interpret creatinine together with eGFR, clinical findings and other tests.
Can kidney function improve?
It depends on the cause. Kidney function affected by an acute and reversible problem may improve significantly. Established chronic kidney disease is generally not fully reversible, but appropriate treatment can slow progression and sometimes stabilize kidney function.
Does kidney disease always cause back pain?
No. Many kidney diseases do not cause pain. Kidney stones, infections and urinary obstruction are more commonly associated with flank or back pain.
Which doctor should I see for kidney problems?
A nephrologist specializes in medical kidney diseases and kidney function. A urologist generally manages structural urinary tract problems and procedures such as stone removal or treatment of urinary obstruction.
Conclusion
Recognizing the signs your kidneys are not working properly can help you seek medical care before kidney disease becomes advanced. Changes in urination, persistent swelling, foamy urine, blood in the urine, fatigue, high blood pressure, itching, nausea and abnormal kidney function tests can all warrant evaluation.
However, symptoms alone cannot determine how well the kidneys are functioning. Blood tests such as creatinine and eGFR, urine testing, blood pressure assessment and imaging when indicated provide a more reliable assessment.
At Prabhakar Bhurke Clinic, Dr. Sandip Prabhakar Bhurke, a super specialist nephrologist, provides comprehensive evaluation and personalized management for kidney disease, acute kidney injury, kidney stones, hypertension-related kidney problems, dialysis and advanced kidney failure.
Early diagnosis, appropriate treatment and regular follow-up can help protect kidney function and support better long-term health.
Book an Appointment Today
If you have swelling, changes in urination, foamy urine, blood in the urine, persistent fatigue, high creatinine, reduced eGFR, high blood pressure, recurrent kidney stones or other concerns about your kidney health, schedule a consultation at Prabhakar Bhurke Clinic.
Dr. Sandip Prabhakar Bhurke, a super specialist nephrologist, can evaluate your kidney function, identify possible causes of abnormal findings and develop an individualized care plan.
Medical Disclaimer
This article is intended for general educational purposes only and does not replace professional medical advice, diagnosis or treatment. Kidney symptoms can have many causes, and kidney function should be assessed using appropriate medical tests. Do not self-medicate or stop prescribed medicines without consulting your healthcare professional. Seek urgent medical attention for severe shortness of breath, chest pain, confusion, loss of consciousness, seizures, very low or no urine output, or severe pain with fever or chills.
